Protein drugs feature significant advantages over small molecule therapeutics, including low toxicity, high specificity, and development speed. However, the quality control requirements are ...

Proteins play a key role in the life sciences - from basic research and biotechnological applications to the development and manufacturing of pharmaceuticals. Scientists at the Technical University of ...

Researchers have developed a method to evaluate the folding stability of a million proteins simultaneously. DNA libraries were used to generate protein -- DNA complexes that were treated with enzymes ...

Drug developers have historically glued their attention to targeting the precise and fine-tuned protein structures underlying biological function. Yet this approach misses over 50% of the human ...

Proteins are made of chains of amino acids, and a basic tenet of biology is that the sequence of amino acids determines how a protein folds into a 3D shape which, in turn, dictates the protein’s ...

In a paper recently published in Nature Communications, the HUN-REN-ELTE Protein Modeling Research Group (Institute of Chemistry) has laid the foundations for a mathematical method, allowing the ...

Understanding the structure of proteins is critical for demystifying their functions and developing drugs that target them. To that end, a team of researchers at Brown University has developed a way ...

Cells operate on rules not vibes, including when on the precipice of persisting or perishing. Yet, with prior research ...

Drug discovery requires two separate steps: checking whether a drug can bind to a harmful molecule or its receptor, and ...