Type I interferons are a family of cytokines that play a critical role in the immune system, particularly in antiviral defence and immunomodulation. In systemic lupus erythematosus (SLE), an ...

Innate immune sensors—known as pattern recognition receptors (PRRs)—detect specific molecular components of bacterial or ...

The emergence and rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered the coronavirus disease 2019 (COVID-19) pandemic. To date, over 118 million cases have been ...

A new study shows that about two percent of the population develop autoantibodies against type 1 interferons, mostly later in life. This makes individuals more susceptible to viral diseases like COVID ...

A growing body of research has identified a hidden immune defect, not written in DNA, that helps explain why certain people ...

Please provide your email address to receive an email when new articles are posted on . “These findings suggest that IFN-I blocking agents may be particularly effective in treating skin manifestations ...

Please provide your email address to receive an email when new articles are posted on . The expression of GSDMB was high in children with a 17q21 genetic variant. These children did not have ...

Known as first responders to viral infection, Type I interferons may also play a part—for better or worse—in neurodegenerative disease. At AD/PD 2022, held March 15-20 online and in Barcelona, Spain, ...

SARS-CoV-2 is the reigning champion of overcoming natural immunity. Infected cells produce interferon, which in turn stimulates an impressive array of hundreds of antiviral genes. SARS-CoV-2 has ...