When our body fights an infection, the immune system must quickly activate defenses and trigger a beneficial inflammatory response. It’s just as important to be able to resolve that inflammation and ...

Innate immune sensors—known as pattern recognition receptors (PRRs)—detect specific molecular components of bacterial or ...

Shi’s study, "Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling," was recently published in Nature Communications. “Concerted efforts ...

Ossification of the posterior longitudinal ligament (OPLL) is a progressive spinal disease characterized by ectopic bone formation in the spine, leading to severe neurological symptoms due to spinal ...

A growing body of research has identified a hidden immune defect, not written in DNA, that helps explain why certain people ...

Interferon signatures may be a candidate biomarker for early identification of response to lupus nephritis induction treatment. Persistent type I interferon-driven transcriptional activity in ...

Hepatitis B virus (HBV) infection remains an urgent global health concern, affecting hundreds of millions of people and significantly heightening the risk of severe liver complications, including ...

Higher baseline expression of interferon (IFN)-driven genes was tied to a better response to methotrexate in patients with juvenile idiopathic arthritis (JIA). Gene enrichment in the IFN-alpha (type I ...

A unique quality of the immune system is that it can generate a ‘memory’ response. This is generally referred to as ‘immune ...